Molecular and functional heterogeneity of inwardly rectifying K+ channels.
نویسندگان
چکیده
منابع مشابه
Distinct Specificities of Inwardly Rectifying K Channels
Activation of several inwardly rectifying K channels (Kir) requires the presence of phosphatidylinositol 4,5bisphosphate (PtdIns(4,5)P2). The constitutively active Kir2.1 (IRK1) channels interact with PtdIns(4,5)P2 strongly, whereas the G-protein activated Kir3.1/3.4 channels (GIRK1/GIRK4), show only weak interactions with PtdIns(4,5)P2. We investigated whether these inwardly rectifying K chann...
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Inwardly rectifying K(+) (Kir) channels respond to receptor-stimulated signaling cascades that involve G proteins and other cytosolic messengers. Channel activity is controlled both by direct coupling of G protein subunits and by phosphorylation via protein serine/threonine and tyrosine kinases. The coincidence of both forms of Kir channel signaling may give rise to complex cellular responses.
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The whole cell patch-clamp technique was used to investigate whether there were inwardly rectifying K(+) (K(ir)) channels in the longitudinal muscle of cat esophagus. Inward currents were observable on membrane hyperpolarization negative to the K(+) equilibrium potential (E(k)) in freshly isolated esophageal longitudinal muscle cells. The current-voltage relationship exhibited strong inward rec...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36310-3